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the in RG7420 vitro studies with the mutants and the caterpillar experiments, analyzed the data and contributed to writing the manuscript. LH conceived the original use of Az against intracellular Francisella and performed the first in vitro studies of Az’s effectiveness, AQ performed the Schu S4 testing, BM designed and coordinated the Schu S4 testing and contributed to the interpretation and conclusions drawn from these studies, MVH conceived of the overall study, designed and coordinated the experiments, and wrote the manuscript. All authors read and approved the final manuscript.”
fragilis is a Gram-negative member of the normal human gut microbiota. The Bacteroidetes constitutes one of the major bacterial phyla in the healthy human gut . However, B. fragilis is also an important opportunistic pathogen, and it is the most frequently isolated anaerobic bacterium in clinical specimens, including abdominal abscesses and bloodstream infections . Indeed, while B. fragilis accounts for only 4 to 13% of the normal human fecal Janus kinase (JAK) microbiota, it is responsible for 63 to 80% of Bacteroides infections . Only a few virulence Dorsomorphin molecular weight factors have been described for B. fragilis, with the best characterized being the polysaccharide (PS) capsule  and a secreted metalloprotease, fragilysin . The capsule, which displays antigenic variation, promotes the formation of abscesses , and the reduction of pro-inflammatory responses to B. fragilis [4, 6]. The metalloprotease fragilysin, which has been linked to diarrheal disease , has activity against the zonula junctions between cells, and could disrupt tissue integrity . B. fragilis also encodes homologues of C10 proteases . These are members of the CA clan of papain-like proteases. Other C10 proteases include the important virulence factors Streptococcal pyrogenic exotoxin B (SpeB) from Streptococcus pyogenes and Interpain A from Prevotella intermedia.