6 degrees C higher than rectal temperature (38.0
+/- 0.7 degrees C, p < 0.01). Survival at endpoint (7/11 vs. 4/4) and average survival time (134 +/- 64 vs. 180 min) were greater for both ACS+ and ACS in comparison to Standard Dressing. The wound temperature with ACS was reduced with greater blood to product ratios Smoothened Agonist concentration and this pattern was paralleled with in vitro measurements. Conclusions The lower heat release with ACS+ compared to ACS was confirmed in an animal model and ACS+ had similar efficacy in arresting bleeding when compared to Standard Dressing.”
“Magalhaes CB, Riva DR, DePaula LJ, Brando-Lima A, Koatz VL, Leal-Cardoso JH, Zin WA, Faffe DS. In vivo anti-inflammatory action of eugenol on lipopolysaccharide-induced lung injury. J Appl Physiol 108: 845-851, 2010. First published January 14, 2010; doi:10.1152/japplphysiol.00560.2009.-Eugenol, a methoxyphenol component of clove oil, suppresses cyclooxygenase-2 expression, while eugenol dimers prevent nuclear factor-kappa B (NF-kappa B) activation and inflammatory cytokine
expression in lipopolysaccharide-stimulated macrophages. Our aim LB-100 mouse was to examine the in vivo anti-inflammatory effects of eugenol. BALB/c mice were divided into four groups. Mice received saline [0.05 ml intratracheally (it), control (Ctrl) and eugenol (Eug) groups] or Escherichia coli LPS (10 kappa g it, LPS and LPSEug groups). After 6 h, mice received saline (0.2 ml ip, Ctrl and LPS groups) or eugenol (160 mg/kg Bromosporine ip, Eug and LPSEug groups). Twenty-four hours after LPS injection, pulmonary
resistive (Delta P1) and viscoelastic (Delta P2) pressures, static elastance (E(st)), and viscoelastic component of elastance (Delta E) were measured. Lungs were prepared for histology. In parallel mice, bronchoalveolar lavage fluid was collected 24 h after LPS injection. TNF-alpha was determined by ELISA. Lung tissue expression of NF-kappa B was determined by EMSA. Delta P1, Delta P2, E(st), and Delta E were significantly higher in the LPS group than in the other groups. LPS mice also showed significantly more alveolar collapse, collagen fibers, and neutrophil influx and higher TNF-alpha levels and NF-kappa B expression than the other groups. Eugenol treatment reduced LPS-induced lung inflammation, improving lung function. Our results suggest that eugenol exhibits in vivo anti-inflammatory action in LPS-induced lung injury.”
“Background: The proposed introduction of the CAB (circulation, airway, breathing) sequence for cardiopulmonary resuscitation has raised some perplexity within the pediatric community. We designed a randomized trial intended to verify if and how much timing of intervention in pediatric cardiopulmonary resuscitation is affected by the use of the CAB vs. the ABC (airway, breathing, circulation) sequence.\n\nPatients and methods: 340 volunteers, paired into 170 two-person teams, performed 2-rescuer healthcare provider BLS with both a CAB and ABC sequence.