We and others are currently studying potential chondroprotective agents that may improve cartilage survival after impact injury. In a study evaluating OCT and its selleckbio ability to detect acute cartilage changes following impact injury, Bear et al. showed significant correlation between histology, chondrocyte death, and OCT grading following impact injury even at energies insufficient to fracture the articular surface (R2 = 0.48, P < .001) [28]. In a pilot study of ACL-injured subjects, OCT was found to detect microscopic subsurface injuries that were predictive of MRI T2 map changes at 6 and 12 months following ACL reconstruction (unpublished data). These data further show a potential for OCT to nondestructively detect microstructural subsurface injuries to articular cartilage that were undetectable by conventional surface examination.
5. Future Directions The potential clinical implications of early diagnosis and staging of acute cartilage injury include supporting a clinical paradigm shift from viewing osteoarthritis as an untreatable degenerative condition to that of a potentially modifiable chronic disease process. Towards this end, laboratory studies show OCT can potentially provide microstructural information on cartilage health that can be used to improve the diagnosis and staging of early cartilage injury and degeneration [7, 24, 28]. Translational clinical studies support the use of OCT arthroscopically for these purposes [5, 8]. Recent technological developments include decreasing the size of the OCT probe to where it can be inserted through an 18 gauge needle, potentially making OCT evaluation of the cartilage an office procedure [29].
Recent studies additionally show OCT to be a powerful translational research tool in assessing the clinical utility of new MRI technologies for noninvasive early detection of cartilage injury and degeneration. Further study of OCT and related new technologies for assessment of articular cartilage will assist in the development of the clinical diagnostic power needed for implementation and evaluation of potential new treatment strategies to delay or prevent the onset of osteoarthritis.
Adenocarcinoma of the paranasal sinuses is rare and generally follows an aggressive clinical course [1]. Craniofacial resection has been the mainstay of treatment for many years now and represents the gold standard of surgical resection.
However, endoscopic techniques for resection are constantly being developed and may represent a viable alternative with fewer complications. As well as this, chemotherapy and radiotherapy are important treatment options and can be used to augment the effects of surgery [2]. In this paper, a patient with sinonasal adenocarcinoma treated by endoscopic resection is presented. 2. Case Report A 66-year-old woman presented for Drug_discovery biopsy of the left ethmoid sinus and nasal cavity in order to assess possible recurrence of ethmoidal adenocarcinoma.