Recovery of brainstem reflexes and improvement of Glasgow Coma Scale (GCS) motor score were noted (postresuscitation neurologic restorative assessment, grade I) in 5, and 2 of these patients survived. Results: By-grade analysis of patient background characteristics revealed a significantly shorter duration of cardiac arrest (P = .001) and a significantly smaller adrenaline dose (P = .011) for grade I patients. A logistic analysis

of 1-week survival data revealed significant differences in duration of cardiac arrest (P = .022) and adrenaline dose (P = .019), with odds ratios of 0.89 and 0.25, respectively. Cox regression analysis LCL161 of mortality data revealed significant differences in the duration of cardiac arrest (P = .012), adrenaline dose (P < .0001), and location of ROSC (P = .016), with hazard ratios of 1.03, 1.43, and 1.98, respectively. Conclusions: Cardiac arrest caused by SAH is a disease state with a grave prognosis, but there is the possibility of a good survival outcome when the administration of a small

dose of adrenaline results in the rapid Semaxanib Protein Tyrosine Kinase inhibitor recovery of brainstem reflexes.”
“Objectives: To propose a multidimensional item response theory (MIRT) scoring system for the Short Form 12 (SF-12) with good psychometric properties in terms of fit and reliability.

Study Design and Settings: Two models, indicating physical (PCS)

and mental BMS-754807 nmr component summary (MCS) dimensions, were fitted to SF-12 data from the European Study of the Epidemiology of Mental Disorders, a representative sample from European adult general population (n = 21,425; response rate = 61.2%). Goodness of fit, information, reliability, and agreement of individual scores were compared with the classical SF-12 and RAND-12 algorithms.

Results: The bidimensional response process (BRP) model, where all items are indicators of both dimensions, yielded the best fit (root mean square error of approximation = 0.057, comparative fit index = 0.95, and Tucker-Lewis index = 0.94), and highly agreed with PCS and MCS scores from the SF-12 (intraclass correlation coefficients of 0.92 and 0.88, respectively) and RAND-12 (0.88 and 0.95). Regarding reliability, the BRP yielded 0.75 and 0.77 (PCS and MCS, respectively), greater than SF-12 (0.65 and 0.66) and RAND-12 (0.65 and 0.67). As indicated by scale linking, MIRT scores can be interpreted similarly to the classical scores.

Conclusion: The MIRT models showed a clear construct structure for the PCS and MCS dimensions, defined by functional and role limitation content. Results support the use of SF-12 MIRT-based scores as a valid and reliable option to assess health status. (C) 2013 Elsevier Inc. All rights reserved.