However, with every technological development comes some element of health concern,
and cell phones are no exception. Recently, various studies have highlighted the negative effects of cell phone exposure on human health, and concerns about possible Crenigacestat order hazards related to cell phone exposure have been growing. This is a comprehensive, up-to-the-minute overview of the effects of cell phone exposure oil human health. The types of cell phones and cell phone technologies currently used in the world are discussed in an attempt to improve the understanding of the technical aspects, including the effect of cell phone exposure on the cardiovascular system, sleep and cognitive function. as well as localized and general adverse effects, genotoxicity potential, CAL-101 manufacturer neurohormonal secretion and tumour induction. The proposed mechanisms by which cell phones adversely affect various aspects of human health, and male fertility in particular, are explained, and the emerging molecular techniques and approaches for elucidating the effects of mobile phone radiation on cellular physiology using high-throughput screening techniques, such as metabolomics and microarrays, are discussed. A
novel study is described. which is looking at changes in semen parameters, oxidative stress markers and sperm DNA damage in semen samples exposed in vitro to cell phone radiation.”
“Purpose: To enhance the solubility and dissolution characteristics of ketoprofen using various crystallization techniques.
Methods: Ketoprofen crystals were prepared by various crystallization technique including spherical check details agglomeration (SA), spray drying (SD), freeze drying (FD) and super cooling (SC). The crystallization medium used for all the techniques consisted of water and chloroform. Residual solvents in the crystals were determined and the crystals were characterized by DSC, FT-IR, XRD and SEM. Both solubility and dissolution behavior studies were carried out. The physical stability of the crystals were also evaluated after storage over a period of time.
Results: Residual IPA and chloroform in the crystals ranged from 4.10 – 5.70 and 1.84 – 2.57 ppm, respectively, which are
well below their toxic limits. The crystals obtained exhibited lower crystallinity than the original drug. The solubility of FD crystals in water increased almost fivefold to 0.0926 mg/ml compared with that of the drug (0.0172 mg/ml), while the dissolution rates of the developed crystals were than that of the original crystals. For example, FD crystals demonstrated the highest dissolution (99.9 %) compared with original crystals (64.3 %). In the stability test, the dissolution profiles of the developed crystals remained largely unchanged over the period of the stability study.
Conclusion: The re-crystallization techniques used in this study can be applied to obtain modified ketoprofen for formulation of tablets of the drug with improved drug dissolution.