We obtained baseline data on omega-3 LCPUFA intake with a validated food-frequency questionnaire. Trained fundus graders ascertained AMD status from annual stereoscopic color photographs by using standardized methods at a single reading center across a 12-y period. We applied multivariable repeated-measures logistic regression with the incorporation of generalized estimating equation methods, because this permitted determination of progression
to outcome at each visit.
Results: Participants who reported the highest omega-3 LCPUFA intake (median: 0.11% of total energy intake) were 30% less likely than their peers Kinase Inhibitor Library to develop CGA and NV AMD. The respective odds ratios were 0.65 (95% CI: 0.45, 0.92; P <= 0.02) and 0.68 (95% CI: 0.49, 0.94; P <= 0.02).
Conclusions: The 12-y incidence of CGA and NV AMD in participants at moderate-to-high risk of these outcomes was lowest for those reporting the highest consumption of omega-3 LCPUFAs. If these results are generalizable, they may guide the development of low-cost and easily implemented preventive interventions for progression to advanced AMD. This trial was registered at clinicaltrials.gov as NCT00594672. Am J Clin Nutr 2009;90:1601-7.”
“Background: Staphylococcus
intermedius is a very rare human pathogen. There are only 16 cases in the literature that have described LGX818 S. intermedius as a cause of infection in humans. Most of these cases have been described in association with exposure to animals, mostly dogs. However, this pathogen can cause infection in healthy selleck chemical individuals even without exposure to animals.
Methods: All previous cases of S. intermedius infection included in our literature review were found using a PubMed search (1960-November 2009) of the English-language medical literature applying the terms ‘Staphylococcus intermedius’, ‘abscess’, ‘infection’, ‘humans’. The references cited
in these articles were examined to identify additional reports.
Results: We describe the first case of skin abscesses caused by S. intermedius in an immunocompetent patient who used intravenous cocaine after coating his syringes with his saliva. We also summarize the literature regarding infections caused by S. intermedius in humans.
Conclusions: This case illustrates for the first time that S. intermedius can cause skin abscesses in humans after direct inoculation of this pathogen into the skin and soft tissues. Clinicians should be aware of the fact that although the vast majority of infections from coagulase-positive Staphylococcus infections are secondary to Staphylococcus aureus, S. intermedius is also a potential pathogen in humans. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Pseudoachondroplasia is an autosomal dominant osteochondrodysplasia characterized by disproportionate short stature, joint laxity, and early onset osteoarthrosis.