This simple tool may be of practical use, especially sellckchem to guide interpretation of individual performances that may appear to initially fall in borderline areas where thresholds between types of impairments are defined. Abbreviations AD: Alzheimer’s disease; ADC: Alzheimer’s Disease Center; ADRC: Alzheimer’s Disease Research Center; BNT: Boston Naming Test; CDR: Clinical Dementia Rating (Scale); FAQ: Functional Assessment Questionnaire; LMIIA: logical memory II, story A; MCI: mild cognitive impairment; MMSE: mini-mental state examination; MV: multivariate models; NACC: National Alzheimer Coordinating Center; NIA-AA: National Institute on Aging and Alzheimer’s Association work-group; NPT: neuropsychological test; RMSE: root mean square error; SAS: Statistical Analysis Software; SPSS: Statistical Package for the Social Sciences; TMT: trail making test; UC: unconditional model; UDS: uniform data set; UV: univariate models; WAIS-R: Wechsler Adult Intelligence Scale-Revised; WMS-R: Wechsler Memory Scale-Revised.

Competing interests The authors declare that they have no competing interests. Authors’ contributions SS was involved in conceptualization of the study, conducted all statistical analysis, and was primarily responsible for drafting the manuscript. MM participated in conceptualization, interpretation of statistical analysis, and drafting and review of the manuscript. LS participated in interpretation of results and provided critical review of manuscript drafts. JS was involved in study conceptualization and provided critical Entinostat review of the manuscript.

JL participated in statistical analysis and provided critical review of the analysis and results sections of the manuscript. SW was involved in study conceptualization and provided critical review of the manuscript. AA was involved in study conceptualization, interpretation of data analysis, drafting of the manuscript, and provided critical selleck chem review of all aspects of data analysis, interpretation, and manuscript preparation. All authors have read and approved the manuscript for publication. Supplementary Material Additional file 1: Normative Calculator for the Uniform Data Set (UDS). Neuropsychological Test Battery with illustrative example of demographics and test performance. Click here for file(40K, XLSX) Additional file 2: Template for researchers to develop their own normative calculator using our methodology. Click here for file(23K, XLSX) Acknowledgements We would like to acknowledge the National Alzheimer’s Coordinating Center (NACC) funded by the National Institute on Aging (U01 “type”:”entrez-nucleotide”,”attrs”:”text”:”AG016976″,”term_id”:”55789945″,”term_text”:”AG016976″AG016976), PI W. Kukull.