This is usually the time when patients with high fever (> 38°C) and severe headache NVP-LDE225 clinical trial seek medical advice. Neurological signs and symptoms may include: meningeal signs, ataxia, (cognitive dysfunction with impaired concentration and memory) dysphasia, altered consciousness, confusion, irritability, cranial nerve paralysis, and tremor. The European strain infection has a case-fatality rate up to 3.9%.3 A 56-year-old retired English man started with his 53-year-old wife a bicycle tour of Europe (Fig. 1). They carefully planned by themselves their itinerary

logistically (accommodation, meals, visas) and also from a health point of view. In fact, they had a full insurance package for health care and for anticipated return to home country in case of health problems. They carried a first-aid kit and some over-the-counter drugs. They did not receive any additional recommendation regarding health risks and preventive measures—in particular regarding TBE—from their family doctor or from the insurance company. Notwithstanding extensive consultation of several websites providing suggestions for bicycle tours in the different crossed countries, they did not come across recommendations

for TBE vaccination strong enough to push them to ask for it. Their travel started on June 12, 2008 from Hamburg on two pedal bicycles with one small ridge tent. They were wearing shorts and T-shirts because of the heat. Their typical accommodation for the night was camping, mostly in wooded areas and the like. During their bike tour, they transited in countries with wide high-risk Gemcitabine supplier areas for TBE transmission (Russia, Estonia, Lithuania) and countries

where TBE can be relevant Verteporfin in limited high-risk areas (Sweden, Finland, Poland, the Czech Republic, Germany, Austria, and Slovenia). The patient detected and, almost always, promptly removed ticks (a total of about 20) on various occasions (Fig. 1) and he and his wife did not change their habits nor their behavior in terms of tick-bite prevention. The patient received tick bites for the first time in the woods of Southern Sweden (20–23 June), then in Finland (25–29 June), Russia (30 June–5 July), Estonia (5–10 July), Lithuania (11–12 July), Russia again in the Kaliningrad exclave (13–15 July), Poland (16–24 July), Germany (15–20 August), Austria (21–23 August), and finally in Slovenia (23–26 August). Nevertheless, the patient and his wife were healthy until crossing the border between Slovenia and Italy (26 August). On that same day, the patient presented fever and headache. During the following days, the patient reported recovery alternating with fever and headache until 15 days later when they arrived in Genoa; he always self-administered paracetamol only. Here, on September 15th, his wife accompanied him to the Emergency Room of our Hospital because of fever, extreme fatigue, headache, and bilateral ear pain.