There were no significant changes in serum BDNF or TrkB protein levels. Conclusion: These findings suggest that serum TrkB protein levels may play an important role in the psychopathology of bipolar mania. However,
a larger sample size is needed to confirm these results. Copyright (C) 2012 S. Karger AG, Basel”
“Rationale Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse.
Objectives In these studies we set out to determine if neuronal nicotinic acetylcholine receptors were involved in the acute locomotor responses to these drugs, our measure of behavioral stimulation.
Methods A panel of acetylcholine receptor antagonists was used to determine if nicotinic receptors were involved GSK2879552 in EtOH- and psychostimulant-induced stimulation. We tested the effect of these drugs in genotypes of mice (FAST and DBA/2J) that are extremely sensitive to this drug effect. To determine which acetylcholine receptor subunits may be involved
in this response, relative expression of the alpha 3, alpha 6, beta Z-VAD-FMK cell line 2, and beta 4 subunit genes was examined in mice selectively bred for high and low response to EtOH.
Results www.selleck.co.jp/products/erlotinib.html Mecamylamine, but not hexamethonium, attenuated the acute locomotor response
to EtOH. The acetylcholine receptor antagonist dihydro-beta-erythroidine and methyllycaconitine had no effect on this response. The alpha 6 and beta 4, but not alpha 3 or beta 2, subunits of the acetylcholine receptor were differentially expressed between mice bred for extreme differences in EtOH stimulation. Mecamylamine had no effect on psychostimulant-induced locomotor activity.
Conclusions Neuronal nicotinic receptors are involved in EtOH, but not psychostimulant, stimulation. These studies suggest a lack of involvement of some nicotinic receptor subtypes, but more work is needed to determine the specific receptor subtypes involved in this behavior.”
“Introduction: Juxtarenal aortic aneurysms (JAA) can be successfully treated by fenestrated/branched endografts (FBE), but with significant cost and a long manufacturing process. “”Chimney”" grafts (CG) have been advocated as a cheaper and immediately available alternative. Because scant data are available, the aim of this study was to report our early experience with CG to treat JAA.
Methods: From 2000 to 2010, data were prospectively collected for 975 consecutive endovascular aortic repairs (EVAR). Among them, 57 patients undergoing EVAR for JAA were retrospectively reviewed, and those undergoing planned CG were analyzed further. All CG patients were thought to be at high risk for open surgery and were usually unsuitable for FBE.