The present study was undertaken to evaluate the characteristics of IPAA in the Chinese LDK378 in vitro population. Methods: A total of 135 patients who underwent IPAA during 1989 to 2011(122 of which received

hand-sewn IPAA with a two-stage operation) were followed up for more than one year. Data collected included the evaluation of surgical features, postoperative complications and anal function measured by stool frequency, the Bristol stool form scale and the Kirwan classification, as well as the Cleveland Global Quality of Life (CGQL) index. Results: As compared with reports from Western countries, a significantly higher percentage of Chinese UC patients from this study who underwent IPAA received a two-stage operation (90.4% vs. 38.0%), implying that the overuse of steroids in UC patients in China lead to the loss of the best opportunity for operation. However, these patients

showed much lower incidence of postoperative complications than those of Western countries (20.7% vs. 62.0%), especially for pouchitis (5.2% vs. 50%), which maybe correlated with Chinese preference of cooked and hot diet. Stool frequencies per 24-hours and per night in postoperative month (POM)-12 were significantly decreased when compared to those of POM-3 (3.9 ± 1.7 vs. 6.1 ± 2.6 per 24-hour, 1.3 ± 0.7 vs. find more 2.8 ± 1.8 per night, p < 0.05). Characteristics of feces in POM-12 were better than those of POM-3 (Grade-IV 52.5% vs. 30.3%, Grade-V 41.8% vs. 50.8%, Grade-VI 5.7% vs. 18.9%, p < 0.05). The prevalence of perfect anal continence after surgery was also higher in Chinese UC patients than that reported in Western countries (89.3% vs. 82.4%),

indicating that hand-sewn-IPAA is important in protecting anal function. In addition, the postoperative CGQL index on POM-12 was much better than that of pre-operation (0.82 ± 0.13 vs. 0.37 ± 0.19, p < 0.05), suggesting that UC patients should receive IPAA as soon as non-surgical treatment fails in order to improve prognosis. Conclusion: Despite the overuse of medchemexpress steroids in Chinese UC patients, hand-sewn-IPAA is a safe and effective surgical treatment as it demonstrates unique advantages of low incidence of post-operative complications, especially pouchitis, for UC patients in China. Key Word(s): 1. IPAA; 2. Chinese population; 3. ulcerative colitis; 4. quality of life; Presenting Author: NING CHEN Additional Authors: YULAN LIU Corresponding Author: NING CHEN Affiliations: Peking University People’s Hospital Objective: Intestinal fibroblasts are important in the pathogenesis of Crohn’s disease (CD). Creeping fat wrapping around involved intestines is one of the characteristics in CD, but with unclear role.