The odds of reporting visual or auditory problems, hearing aid use or abnormal vision or hearing being found on examination were similar amongst cases and controls. Equally, the odds of reporting spinal stenosis, or an operation for spinal stenosis, were similar amongst cases and controls (adjusted OR 0.98

[0.39, 2.45], p = 0.959, adjusted Momelotinib order for gender and age). Similarly the odds of cranial nerve palsy were no NVP-BGJ398 higher amongst HBM cases compared with controls (adjusted OR 1.38 [0.51, 3.70], p = 0.522). There was a weak trend towards increased reporting of carpal tunnel syndrome amongst HBM cases. Renal calculi and osteomyelitis were no more commonly reported amongst cases than controls and were infrequent. Table 4 The structural and symptomatic bone phenotype of high bone mass cases compared with unaffected relatives and spouses   n (555) HBM n (%; n = 355) Control n (%; n = 200) Unadjusted OR (95% CI) Unadjusted p value Adjusted OR (95% CI)h Adjusted p valueh The structural bone phenotype

Mandible enlargement 431 106 (37.9) 24 (15.9) 3.22 (1.96, 5.31) <0.001 4.16 (2.34, 7.39) <0.001 Broad frame 352 119 (55.9) 52 (37.4) 2.12 (1.37, 3.28) 0.001 3.55 (2.12, 5.95) <0.001 Shoe size (UK sizing)a 463 7.1 (6.9, 7.3) 7.9 (7.6, 8.2) −0.8 (−1.2, −0.4) <0.001 0.4 (0.1, 0.7) 0.009 Misshapen or extra bone reported 545 64 (18.2) 26 (13.4) 1.47 (0.88, LY2874455 2.46) 0.137 1.77 (1.00, 3.14) 0.051 Misshapen or extra bone on examinationb 421 59 (21.6) 21 (14.2) 1.67 (0.97, 2.87) 0.066 2.07 (1.13, 3.78) 0.018 Torus palatinus and torus mandibularis 449 92 (31.5) 49 (31.2) 1.01 (0.67, 1.54) 0.949 1.50 (0.92, 2.44) 0.106 Dental overcrowding 483 93 (30.0) 60 (34.7) 0.81 (0.54, 1.20) 0.291 0.84 (0.53, 1.32) 0.447 Report of oral structural abnormalityc 546 29 (8.3) 10 (5.1) 1.69 (0.79, 3.61) 0.172 2.05 (0.89, 4.70) 0.091 Webbing of toes 391 13 (5.2) 6 (4.2) 1.25 (0.46, 3.36) 0.660 1.56 (0.50, 4.90) 0.442 Hammer Aurora Kinase toes 501 44 (13.4) 9 (5.2) 2.80 (1.33, 5.87) 0.007 2.17 (0.96, 4.91) 0.063 Carpal tunnel syndromed 555 21 (5.9) 5 (2.5) 2.56 (0.92, 7.07) 0.070 1.98 (0.69, 5.68) 0.203 Abnormal spine 408 106 (40.3) 35 (24.1) 2.12 (1.35, 3.34) 0.001 1.68 (0.99,

2.85) 0.053 Spinal kyphosis 501 25 (7.6) 10 (5.8) 1.33 (0.62, 2.84) 0.458 0.81 (0.34, 1.90) 0.627 Spinal scoliosis 501 19 (5.8) 3 (1.7) 3.47 (1.00, 12.05) 0.050 3.35 (0.87, 12.87) 0.078 Categories of buoyancy Floats 517 171 (48.6) 143 (72.6) 1.00 <0.001 1.00 <0.001 Struggles to float 26 (7.4) 16 (8.1) 1.39 (0.69, 2.81) 1.93 (0.89, 4.19) Sinks 116 (33)g 15 (7.6) 6.98 (3.77, 12.92) 7.11 (3.65, 13.84) Unable to swim 19 (5.4) 11 (5.6) 1.45 (0.64, 3.28) 1.09 (0.42, 2.82) Fracture history Ever fractured 550 134 (38) 90 (45.7) 0.72 (0.50, 1.04) 0.080 1.03 (0.67, 1.56)i 0.908i Fragility fracture 224 19 (14.2) 16 (17.8) 0.76 (0.37, 1.58) 0.468 0.56 (0.24, 1.29)i 0.173i RTA-related fracture 224 12 (9.0) 5 (5.6) 1.67 (0.57, 4.92) 0.351 1.