Peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) in the ophthalmic artery were measured by color Doppler imaging. Values of PSV, EDV and RI were compared at various IOPs via Metabolism inhibitor the analysis of variance (ANOVA) of a randomized block design with post hoc Bonferroni test.
Results Significant differences of PSV, EDV and RI at different IOP points (all P < 0.001) were observed. Over the entire IOP range, linear regression showed a negative correlation between IOP and both PSV and EDV (beta = -0.07434, P = 0.0020 and beta = -0.07829, P < 0.001,
respectively), as well as a positive correlation between the RI and IOP (beta = 0.00221, P < 0.001). Moreover, line plots identified a point with IOP = 40 mmHg, splitting the IOP range with different regression slopes. Piecewise linear regression indicated no correlation between PSV, EDV, RI and IOP when the IOP was elevated from 20 to 40 mmHg (P = 0.1832, P = 0.5932 and P = 0.5819, respectively). However, piecewise linear regression detected a stronger negative correlation between PSV, EDV and IOP (beta = -0.15760, P = 0.0011 and beta = -0.11872, P = 0.001, respectively) and a stronger positive correlation between RI and IOP (beta = 0.00273, P = 0.0015) during the stage from
40 to 70 mmHg.
Conclusions The ophthalmic artery in the rabbits was capable of maintaining normal blood velocity and resistance when IOP was below 40 mmHg. However, the autoregulatory capacity was greatly limited when IOP was over 40 mmHg.”
“Being rich in polyphenolic compounds such as flavonoids, green tea is suggested to be a potential candidate for the treatment of obesity, AZD4547 order stress, depression, Parkinson’s and other disorders. Since serotonin has an important role in the pathophysiology of these disorders, present study was selleck kinase inhibitor designed to monitor the effects of green tea in rats. Green tea extract was provided to the male Albino Wistar rats for 5 weeks,
and effects on behaviors were monitored. Results show a decrease in food intake after 5th week but not before. An increase in locomotive activities of the animals was observed, as monitored in novel as well as in familiar environment. Anxiolytic effects were observed in elevated plus maze but not in light dark activity box. An increase in dopamine and serotonin turnover was observed. Our results suggest that beneficial effects of green tea drinking might be due to alteration of serotonin and/or dopamine metabolism. We thereby propose that in further experiments, green tea should be administered in animal model of learned helplessness and effects on the development of adaptation to stress should be monitored. Neurochemical estimations of catecholamine and indoleamine in these animal models of stress exposed to green tea would help in understanding the anxiolytic effects of green tea.”
“Background: Collecting population data on sensitive issues such as non-suicidal self-injury (NSSI) is problematic.