Our objective

was to understand how evidence was used by different discussants in the aforementioned arguments and to integrate scientific findings with societal and ethical concerns. By categorizing these arguments, we also aimed to inform policy makers in the country for evidence based action. Based on our initial understanding of the debate two key areas were selected for literature review, (a) ‘epidemiology’ buy Navitoclax and (b) ‘vaccine’; another subsidiary area chosen for review was ‘debate’. We adopted a thorough search strategy, followed by data screening. We searched PubMed and Embase (two bibliographic databases) using identical search terms to retrieve articles on identified areas published in English till September 2013. We did not specify any start-time of publication while conducting this search. Under

‘epidemiology’ we searched PubMed with ‘rotavirus’ (‘rotavirus’ OR ‘rotavirus infections’) as Medical Subject Heading (MeSH) major term, paired with MeSH subheading term ‘epidemiology’ and text word ‘India’. For Embase search, ‘rotavirus’ and ‘epidemiology’ as subject heading terms were paired with the text word ‘India’. A similar search strategy as above was followed for ‘vaccine’ with a single change: the term ‘epidemiology’ was replaced by MeSH major term ‘rotavirus vaccines’ OR ‘vaccines’ OR ‘vaccination’ in PubMed. These three subject heading terms were similarly paired for searching in Bortezomib mw Embase. Articles highlighting ‘debate’ featured in our rotavirus vaccine search. However, in order to obtain wider perspective of the debate, the terms ‘perceptions’, ‘policy’, ‘debate’, ‘importan*’, ‘necess*’ were combined with the terms ‘vaccines’ AND ‘India’, in both bibliographic databases. Apart from PubMed and Embase, we searched the Cochrane Library to identify systematic reviews or meta-analyses on rotavirus vaccine. When searched with rotavirus vaccine as a MeSH term, two meta-analyses [13] and [14] were identified, one published in 2004 and the other in 2012,

Oxygenase conducted by the same group of authors. Bibliographies of retrieved articles were reviewed for additional citations and accessed. Experts in the field were also consulted to obtain articles that might have been missed in the above mentioned search. Full texts of the manuscripts were accessed which included articles, letters and short communications. We excluded conference abstracts, studies not focussed on India, rotavirus infection in animals and articles on clinical management. Duplicates in databases were sorted and the numbers of articles finally selected are presented in Fig. 2. Bibliographies were managed by EndNote (version 5.0.1). The data for our analyses was text obtained through the aforementioned search process. The aim in the first phase of analyses was to familiarize ourselves with the various arguments used to arrive at conclusions.