Improvements in the manufacturing of metal-on-metal bearings over the past 50 years have resulted in implants that provide low wear rates and allow for the use of large femoral heads. However, concerns remain regarding elevated serum metal ion levels, potential teratogenic effects and potentially devastating adverse local tissue reactions, whose incidence and pathogenesis remains

unclear. Modern total hip resurfacing has shown excellent outcomes over 10 years in the hands of experienced surgeons. Current ceramic-on-ceramic bearings have demonstrated excellent survival with exceptionally low wear rates and virtually no local adverse effects. Concerns remain for insertional chipping, in vivo fracture and the variable incidence of squeaking. Contemporary ceramic-on-metal interfaces are in the early stages of clinical use, CA4P mouse with little data reported to date. Hard-on-hard bearings

for total hip arthroplasty have improved see more dramatically over the past 50 years. As bearing designs continue to improve with new and modified materials and improved manufacturing techniques, it is likely that the use of hard-on-hard bearings will continue to increase, especially in young and active patients.”
“In this case-control pilot study a recent method based on HPLC hyphenated to ICP-MS was employed for the quantification of serum glutathione peroxidase type 3 (GPx3), seleno-protein P (SelP) and seleno-albumin (SeAlb) in 42 patients with colorectal cancer (CRC) and 20 controls. Patients with early cancer stage (TNM I) showed a significantly higher level of SeAlb (19 +/- 3 ng/mL) in respect to both metastatic CRC patients (TNM IV, 16 +/- 4 ng/mL) and healthy controls (16 +/- 3 ng/mL). Classification models based on logistic regression analysis, classification trees and artificial neural networks were constructed using seleno-proteins concentrations as predictors. Neural networks lead to the best selleckchem performances, up to 95% of corrected predictions in TNM I vs. controls discrimination. These results suggest a potential association between individual seleno-proteins and CRC progression. Age and radiochemoteraphy were assessed

as confounding factors, showing no significant effects. Still. SeAlb level tended to reduce with the age in healthy persons, but did not in CRC patients. Seleno-proteins concentration was also compared with a number of clinical parameters considered as prognostic factors in CRC. Significant Spearman’s correlations were revealed between SelP and SeAlb, and presence of peritumoural lymphocytic infiltration (rho = -0.57 and rho = -0.37, respectively); and SeAlb and degree of cellular differentiation (grading, rho = -0.37). This study marks the importance to systematically introduce speciation analysis and multidisciplinary approaches in the investigation of the role of seleno-proteins as a potential combined biomarker for CRC. (c) 2012 Elsevier B.V. All rights reserved.”
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