Distraction had no effect on primary motor cortex activity when the dominant hand moved. This finding indicates that distraction by a demanding cognitive task Axitinib VEGFR1 drains resources in the sense of a push/pull mechanism from primary motor cortex only when the neuronal representation of the movement is less efficient as it is the case with the less well-trained, nondominant hand. Simple, externally paced finger tapping with the dominant hand, Inhibitors,research,lifescience,medical on the other side, can be considered such an overlearned, heavily trained task that even performing a cognitive task simultaneously does not compromise its very efficient representation in the activated primary

motor cortex network, although the dual task per se activates additional higher motor

areas. In this respect, it is noteworthy that in everyday life, one can often observe persons who make rhythmic movements with their hands (e.g., tapping on the desk, playing with a pen) when engaged in demanding cognitive tasks. Inhibitors,research,lifescience,medical It is easily conceivable that with a less well-trained and internally paced motor task, like making U-type movements (Binkofski et al. 2002) activity changes in primary motor cortex during distraction could have been observed with the dominant hand as well. The finding that the activity reduction in the nondominant motor cortex did not affect Inhibitors,research,lifescience,medical behavioral performance in our view again is attributable to the fact that a Inhibitors,research,lifescience,medical very simple task was performed. With a more demanding, less well-trained task the activity reduction likely would have been accompanied with behavioral deficits. Hence, we propose that whether attention-related modulation of the primary motor cortex activity occurs depends on the routine and complexity of the motor task. Differentiation between 4a and 4p In this study, no differences in attention-dependent neuronal activation emerged between the more medial, posterior, and inferior finger area, presumably representing area Inhibitors,research,lifescience,medical 4p, and the more lateral, anterior, and superior part of the finger

area, presumably representing area 4a. Previous inhibitor Tubacin studies which observed such differences (Johansen-Berg and Matthews 2002; Binkofski Dacomitinib et al. 2002) defined 4a and 4p anatomically for their ROI analysis, whereas we divided the functionally identified active finger area in the more medial part close to area 3 and the more lateral part close to area 6. Binkofski et al. (2002) verified their anatomical definition of regions with probabilistic maps of postmortem brains and could demonstrate a clear linear relationship between motor attention and neuronal activity exclusively in 4p of the contralateral hemisphere. Johansen-Berg and Matthews (2002) chose an anatomically less strict definition, and observed not only a significant effect in 4p but also – at least a nominal significant– decrease of activation in 4a of the contralateral hemisphere.