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exercise on the activity levels of catalase in various tissues of male and female rats. Cell Biol Int 1999, 23:749–753.CrossRef 31. Taysi S, Oztasan N, Efe H, Polat MF, Gumustekin K, Siktar E, Canakci E, Akcay F, Dane S, Gul M: Endurance training attenuates the oxidative stress due to acute exhaustive exercise in rat liver. Acta Physiol Hung 2008, 95:337–347.PubMedCrossRef 32. Geng JW, Peng W, Huang YG, Fan H, Li SD: Ginsenoside-Rg1 from Panax notoginseng prevents

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“Background Diabetes Mellitus AP26113 (DM) and obesity represent an annual cost of $132 and $147 billion dollars, respectively, for the United States Healthcare System [1–3]. Their incidence and severity have increased since the 1970s and it is estimated that by 2050 one third of the population in the United States will suffer from DM and half will be overweight or obese [4, 5]. In Mexico, the problem is no less impressive since from 1988 to 2006 the prevalence of overweight and obesity went from 35% to 70% and the prevalence of DM in 2006 was almost 15% [6, 7]. Obesity is one of the risk factors with the greatest impact on the

development of DM and BMN-673 insulin resistance. The latter abnormality together with pancreatic beta cell dysfunction represent the initial pathophysiologic basis of type 2 DM [8, 9]. Other important mechanisms have recently been identified, such as entero-insular axis dysfunction, increase 4-Aminobutyrate aminotransferase in glucagon secretion, impaired renal reabsorption of glucose, brain insulin resistance, and lipotoxicity [10–16]. Impairment in long-chain acylcarnitine (AC) transfer to the mitochondrial matrix that results from dysfunction of carnitine palmitoyltransferase-1 (CPT1), leads to the accumulation of AC in cells [17, 18]. This abnormality is one of the causes of lipotoxicity, which has been implicated as one of the mechanisms responsible for insulin resistance in liver and muscle, and of pancreatic beta cell dysfunction [19–21]. It is still debated whether this mitochondrial dysfunction is inherited or acquired and whether or not it is reversible.