Conclusion: Serrated polyps seem to be markers of advanced colonic neoplasia and synchronous cancer. These patients should be regarded as alternate accelerated pathway of colorectal neoplasia and undergo more frequent surveillance colonoscopies then previously thought. (1)  Rondagh et al. Endoscopy 2011; 43 Key Word(s): 1. Serrated Polyps; 2. Colorectal Neoplasia; 3. Serrated Polyposis; Presenting Author: SUNLI YING Corresponding Author: SUNLI YING Affiliations: The First Affiliated Hospital of Harbin Medical University Objective: To investigate the therapeutic effect of saccharomyces boulardii (Sb) in ulcerative colitis through observation of it’s serum level of IL-8 and

IFN-γin TNBS-induced PD-332991 rat colitis. Methods: forty male Wister rats (250–300 g) were randomized into four groups containing ten rats each, namely, colitis groups (group A and B and C), normal control group (group D).Then group A was given SB(800 mg/kg.d),group B was given SASP(200 mg/kg.d),while group C was given 1 ml normal saline for seven days. All of the rats were anesthetized, take blood and colon tissue. Expression of serum level IL-8 and IFN-γwere detected using ELISA, the intestinal tissue were detected by immunohistochemical staining. Results: Campared with group C, DAI scores(1.62 ± 0.73, 1.34 ± 0.605

vs 2.93 ± 0.752) and the serum level IL-8 and IFN-γ (536.32 ± 38.916, 400.38 ± 34.146 vs 783.05 ± 49.522; 328 ± 23.166, AZD2281 manufacturer 196 ± 25.642 vs 492 ± 44.244)and the intestinal tissue level IL-8 and IFN-γwere notably lower in group A and group B(P < 0.01),

they were expressed much higher in group A campared with group D (P < 0.01). Campared group A and B, the serum level IL-8 and IFN-γand the intestinal tissue level IFN-γ were higher (P < 0.05), but the intestinal tissue level IL-8 and DAI scores were expressed no difference (P = 0.314, P = 0.139). Conclusion: There is therapeutic effect with Sb for UC, which MCE may be related to reduce serum and intestinal tissue level of IL-8 and IFN-γ. Key Word(s): 1. ulcerative colitis; 2. SASP; Presenting Author: CHANG QING YIN Corresponding Author: CHANG QING YIN Objective: To observe the expression and clinical significance of E-cadherin (E-CAD) and Matrix metalloproteinase-7 (MMP-7)in colorectal carcinoma. Methods: Expression of E-CAD and MMP-7 in 20 cases of normal colorectal mucosa, 34 cases of colorectal adenoma and 62 cases of colorectal carcinoma was determined by immunohistochemical staining, and relationship between E-CAD and MMP-7 expression and pathological features in 62 cases of colorectal carcinoma. Results: The positive expression of E-CAD in normal colorectal mucosa was significantly higher than those in adenoma and colorectal carcinoma. In colorectal carcinoma and adenoma, the positive expression of MMP-7 was significantly higher than those in normal colorectal mucosa. The expression of E-CAD was decreased and that of MMP-7 was increased with Dukes stage and depth of invasion rising and lymph node transferring.