Comprehensive care and advances in haemostatic treatments have made it possible to safely perform a wide array of surgical procedures, specifically in patients with inhibitors, although restricted access to haemostatic treatments and comprehensive care in the developing world poses

additional challenges in the Nutlin-3 purchase surgical management of patients with CHwI. A coordinated series of peri- and intraoperative events carried out by the multidisciplinary HTC team will ensure optimal outcome in patients with CHwI undergoing surgery. Dr. Kulkarni contributed to the conceptualization, content and composition of this manuscript. Writing assistance was provided by Lara Primak, MD, of ETHOS Health Communications in Newtown, Pennsylvania, USA, with financial Small molecule library clinical trial support from Novo Nordisk Inc, in compliance with international Good Publication Practice guidelines. Dr. Kulkarni received no remuneration of any kind for the development of this manuscript. Roshni Kulkarni is a consultant for Novo Nordisk, Baxter, Bayer, Octapharma and CSL Behring; is on the speakers’ bureau for Novo Nordisk and CSL Behring; and participates in clinical research protocols for Novo Nordisk, Baxter and Biogen Idec. “
“Summary.  Local and national haemophilia registries are powerful instruments to support the healthcare and researchers and improve the communication between Comprehensive Haemophilia Diagnostic and Treatment Centres

(HTCs) and patients. Hemo@care is an example of a Local Haemophilia Registry Systems (LHR_Sys) based on the Web, developed in collaboration

with a HTC located in Portugal, to support the haemophilia treatments registry, collect and manage the clinical information and provide mechanisms to control the clotting factor concentrates (CFC) stock. To extend this solution (the hemo@care) to other Portuguese HTCs and consequently to meet the preconditions to create a National Haemophilia Registry Systems (NHR_Sys), a study based on a questionnaire was carried out at nationwide. This study aims to assess the conditions and motivations of people with haemophilia (PWH) geographically scattered throughout the country, to use a potential Web-enabled registry with the purpose of replacing the traditional paper-diaries, to understand their judgment about a 上海皓元医药股份有限公司 potential NHR_Sys currently non-existent in Portugal, and at the same time, to characterize demographically and pathologically those people at the nationwide. The results based on the analysis of 168 responses (response rate of 31%) confirmed the high prevalence of the disease in haemophilia A (75%) compared with haemophilia B (11.3%) and a large incidence in the severe levels, or the existence of people with mild severity without diagnosis and treatment. Furthermore, the results also revealed the need, conditions and motivation for using a registry system by PWH; thus it is deemed to justify the extension of the hemo@care to other HTCs in Portugal and consequently to create the NHR_Sys. “
“Summary.