Compound

1 is the first example of a taxane HIF inhibitor with 13-glycosidic linkage.”
“A new potential approximation known as modified Becke-Johnson based on density functional theory is applied to compute the electronic band profile and optical response of CdIn2O4, CdGa2O4 and CdAl2O4 compounds. The direct band gap with common LDA, GGA and EV-GGA is drastically underestimated compared with modified Becke-Johnson approximation, whose results are significantly closer to the experimental findings. The optical properties like dielectric constant, refractive index, reflectivity, optical conductivity and absorption coefficient are also computed. A unique characteristic associated with cation replacement is studied; the replacement of cation In by Ga and Ga by Al significantly reduces the direct energy band gap in these compounds. This variation is of crucial importance for band gap dependent optical properties of these compounds, which is also proof for applications of these compounds in optoelectronic devices.”
“Injectable drug nanocarriers have greatly benefited in their clinical development from the addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The most studied and used polymer for this purpose is poly(ethylene glycol), PEG. However, in spite of its wide use for over two decades now, there is no general consensus on the optimum PEG chain coverage-density and

size required to escape from the mononuclear phagocyte system and to extend the

circulation time. Moreover, cellular uptake and active targeting may have conflicting requirements in terms of surface properties of the nanocarriers which Compound Library high throughput complicate even more the optimization process. These persistent issues can be largely attributed to the lack of straightforward characterization techniques to assess the coverage-density, the conformation or 17DMAG mw the thickness of a PEG layer grafted or adsorbed on a particulate drug carrier and is certainly one of the main reasons why so few clinical applications involving PEG coated particle-based drug delivery systems are under clinical trial so far. The objective of this review is to provide the reader with a brief description of the most relevant techniques used to assess qualitatively or quantitatively PEG chain coverage-density, conformation and layer thickness on polymeric nanoparticles. Emphasis has been made on polymeric particle (solid core) either made of copolymers containing PEG chains or modified after particle formation. Advantages and limitations of each technique are presented as well as methods to calculate PEG coverage-density and to investigate PEG chains conformation on the NP surface. (C) 2014 Elsevier B.V. All rights reserved.”
“Background: In 2010, Nicaragua became the first developing nation to add 13-valent pneumococcal conjugate vaccine (PCV-13) to its national immunization schedule, using a “3+0″ dosing schedule.