7 55.7 59.7 57.3  Goal blood pressure <140/90 mmHg (%) 45.7 62.5 66.3 66.1 Per-protocol analysis (n = 449)  Goal blood pressure <140/90 mmHg, or <130/80 mmHg in diabetic patients (%) 42.8 60.5 65.3 62.6  Goal blood pressure <140/90 mmHg (%) 49.2 67.9 72.5 72.2 Fig. 3 Percentage selleck chemicals llc of patients who achieved the goal blood pressure (<140/90 mmHg) at various dosages: a intention-to-treat analysis;

b per-protocol analysis In the per-protocol analysis, similar findings were observed with regard to blood pressure changes from baseline and the percentages of patients who achieved the goal blood pressure (Table 2; Fig. 3). Table 3 Subgroup analysis on the blood pressure-lowering efficacy in the intention-to-treat analysis Parameter n Change in blood pressure Rate of attainment of goal blood pressure STA-9090 supplier Systolic Diastolic <140/90 mmHg <130/80 mmHg (in diabetic patients) mmHg; mean ± SD p value mmHg; mean ± SD p value Patients (%) p value Patients (%) p value Sex  Male 237 −26.6 ± 15.1 0.07 −13.7 ± 10.9 0.59 63.7 0.29 54.0 0.16  Female 264 −28.8 ± 15.8   −13.3 ± 10.1   68.2   60.2 Age  <55 years 246 −28.3 ± 15.4 0.75 −15.9 ± 9.6 <0.0001 68.3 0.30 59.8 0.27  ≥55 years 255 −27.3 ± 15.6   −11.2 ± 10.8   63.9   54.9 Body mass index  <25 kg/m² 209 −29.4 ± 15.0 0.10 −14.1 ± 10.5 0.30 75.1 0.0003 64.1

0.009  ≥25 kg/m² 292 −26.6 ± 15.7   −13.0 ± 10.5   59.6   52.4   Isolated systolic AZD1480 supplier hypertensiona  No 414 −28.0 ± 15.7 0.97 −15.8 ± 9.5 <0.0001 66.4 0.71 58.0 0.5  Yes 87 −26.9 ± 14.7   −2.65 ± 8.0   64.4   54.0 Diabetes mellitusb  No 416 −27.0 ± 15.3 0.007 −13.7 ± 10.5 0.30 65.1 0.33 65.1 <0.0001  Yes 85 −31.3 ± 15.8   −12.4 ± 10.2   70.6   18.8 Left ventricular hypertrophyc  No 233 −27.2 ± 14.6 0.34 −13.4 ± 10.3 0.87 66.5 0.71 57.9 0.72  Yes 245 −28.4 ± 16.4   −13.6 ± 11.0   64.9   56.3 Chronic kidney diseased  No 326 −28.7 ± 14.1 0.07 −13.6 ± 10.3 0.77 73.0 <0.0001 62.6 0.001  Yes 175 −26.0 ± 17.7   −13.3 ± 10.9   53.1   47.4 aDefined as a systolic blood

pressure of at least 160 mmHg and a diastolic blood pressure less than 90 mmHg bDefined as a fasting plasma glucose concentration from 7.1 to 11.0 mmol/l, or as the use of antidiabetic drugs or insulin cDefined as a left ventricular Vasopressin Receptor mass index of at least 112 g/m² in men and 105 g/m² in women dDefined as albuminuria or a serum creatinine concentration from 132.6 to 176.8 μmol/l in men and from 123.8 to 176.8 μmol/l in women 3.3 Determinants of Antihypertensive Efficacy In multiple logistic regression analysis of the intention-to-treat study sample, we identified male sex [odds ratio (OR) 1.73, 95 % confidence interval (CI) 1.16–2.56; p = 0.007] and baseline systolic blood pressure (+10 mmHg; OR 1.59, 95 % CI 1.31–1.92; p < 0.0001) and diastolic blood pressure (+5 mmHg; OR 1.17, 95 % CI 1.04–1.32; p = 0.