(Acta Cytol 2009;53:341-343)”
“Antiepileptic drugs (AED) had an effect on bone metabolism in children. This study was conducted in order to determine the relationships between serum leptin levels, bone mineral density (BMD) and bone turnover markers in epileptic children. Fifty-three patients were treated with valproic acid (VPA) and 23 with carbamazepine (CBZ) monotherapy; 50 healthy selleckchem children were included in the study as controls. Serum alkaline phosphatase (ALP) and cross-linked C-telopeptide (CTx) levels were statistically significantly higher in the CBZ group than in the VPA group and the control group (p<0.0001, p<0.010, respectively). Serum osteocalcin
and ALP levels were significantly lower in the VPA group than in the control group (P<0.012, P<0.030, respectively). Although we found slightly higher serum leptin levels in
both the CBZ and VPA groups, they were not significantly different from the control group (P>0.05). We demonstrated that the markers of bone formation and resorption increased with CBZ and decreased with VPA treatment without affecting BMD and vitamin D levels in prepubertal epileptic children.”
“Background
Micropapillary carcinoma is a rare but unique histologic variant of urothelial carcinoma with an aggressive clinical course. In spite of well-defined clinicopathologic characteristics, the cytomorphologic features in urine specimens have been only rarely described.
Case
A 78-year-old man presented with gross hematuria, showing a large mass on cystoscopy. Urine cytology contained tight clusters of atypical cells, originally interpreted as high-grade urothelial carcinoma or adenocarcinoma. GSK1838705A mw Filial diagnosis was made by histology and immunohistochemical study. On retrospective cytologic review, most presented as small cohesive cellular clusters
in the clean background, showing micropapillae without fibrovascular core, morules and occasional rosette-like microacinar structures. A small number of singly scattered cells were also noted. Tumor cells had high-grade nuclear features and occasional cytoplasmic vacuoles. The inside-out pattern was confirmed oil cell block by immunohistochemistry for epithelial membrane antigen. Immunoreactivity of E-cadherin disappeared, especially in the cytoplasmic membrane toward the fibrocollagenous stroma.
Conclusion
Micropapillary carcinoma had a somewhat characteristic cytologic appearance this website reflecting part of the histologic features. cytopathologists should keep in mind the possibility of this rare entity when evaluating small papillary tumor clusters. Careful cytologic examination in combination with cell block morphology and immunohistochemistry may allow early accurate diagnosis and appropriate management. (Acta Cytol 2009;5 3:344-348)”
“Objective: To examine the associations between morning cortisol and adiposity in children at baseline and 9-month follow-up.
Methods: Participants included 649 (301 males, 348 females) children (9.6+/-0.