With this simple task, no effect for the dominant hand or for concentration instructions was seen in the primary motor cortex. Usage of dominant versus nondominant hand, complexity of both motor and attention task, and training status seem to be relevant factors that determine attention-related activity modulations in the primary sensorimotor cortex. Acknowledgments Work was performed at the Brain Imaging Center in Frankfurt/Main, Germany. Conflict of Interest None declared. Supporting Information Additional Supporting Information may be found in the online version of this article: Table S1. The results of the whole-brain fMRI analysis for right-handers main effect Inhibitors,research,lifescience,medical of attention. Table S2.

The results of the whole-brain fMRI analysis for left-handers main effect of attention. Click here to view.(68K, docx)
The early years are now known to play an important role in the genesis of adult health and disease. Current theory development seeks to explain complex perinatal mechanisms Inhibitors,research,lifescience,medical influencing the developmental origin of health and disease. The early psychosocial experiences of mothers and infants are of special significance to the development

of secure mother–infant attachment with its positive impact on cognitive, emotional, social, and behavioral development. The aim of the study reported here is Inhibitors,research,lifescience,medical to identify latent variables that can be used to inform the building of theoretical models of perinatal influences on postnatal depression and maternal–infant attachment. Postnatal depression has been estimated to affect 13–20% of women in GDC-0973 nmr studies carried out in industrialized Inhibitors,research,lifescience,medical nations (Gavin et al. 2005). Similar rates have also been found in large Australian studies (Buist et al. 2008; Eastwood et al. 2011). Psychosocial risk factors that have been implicated include history of mental illness, lack of

social support, recent life stresses, personality variables, and negative feelings about pregnancy or parenthood (Austin and Priest 2005; Barnett et al. 2005). Beck, in her 2001 meta-analysis of 84 published studies, identified 13 significant predictors Inhibitors,research,lifescience,medical of postnatal depression. They were prenatal depression, self esteem, childcare stress, prenatal anxiety, life stress, social support, marital relationship, history of previous depression, infant temperament, maternity blues, marital status, socioeconomic status, and unplanned/unwanted all pregnancy (Beck 2001). The effect of maternal depressed mood on child development has been extensively studied. A meta-analysis of 46 observational studies of depressed mothers demonstrated a moderate association of maternal depression with negative (i.e., hostile, coercive) parenting behaviors and disengaged parenting behaviors (Lovejoy et al. 2000). The effects were strongest for studies of disadvantaged women. Maternal postnatal depression has also been shown to be associated with impairment of cognitive development and secure attachment (Cogill et al. 1986; Murray et al. 1996).