Discussion: The present study in anesthetized guinea pigs indicates that negative E-M windows are a prerequisite for sympathetically-driven TdP induction after the administration of various agents with known proarrhythmic potential. These data are a first step in the validation of this novel protocol; however we believe that this proarrhythmia model in small animals might be a valuable additional tool in the prediction of TdP risk of new chemical entities at the early stages of drug discovery. (C) 2012

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“It has been suggested that upper-body fat compared with lower-body fat is more closely associated with cardiovascular abnormalities. Our objective was to analyze the relationship between central fat (CF) and cardiac autonomic (cANS) function in obese and CA3 overweight girls. Children were classified in two groups based on CF: those above (CFa(50)) and those below the 50th percentile (CFb(50)) of the entire sample. This study

included 16 female children who were diagnosed as being overweight or obese (age: 14.3 +/- A 2.8 years; weight: 75.0 +/- A 15.8 kg; height: 157.1 +/- A 8.9 cm; body mass index: 30.1 +/- A 5.4; and total body fat: 40.5 +/- A 5.0%; Tanner stage: 4). cANS function was assessed through heart rate variability (HRV) and CF parameters by dual-energy X-ray absorptiometry. Female children with higher CF exhibited significantly higher sympathetic and lower parasympathetic modulation than

those with lower CF, independently of total body fat. selleck inhibitor The data of the present study indicate that CF is associated with less favorable indexes of HRV. In addition, our findings suggest that CF might be an important measure to assess the effect of obesity on cANS function in female children.”
“Atherosclerosis is an inflammatory disease, and ischemic stroke is one of its most common and devastating manifestations. Proinflammatory cytokines play a key role in the progression of the irreversible ischemic lesions. The presence of anti-inflammatory mediators may prevent VX-809 research buy secondary ischemic injury. Objectives: 1) To assess the relationship between stroke severity and the serum Levels of IL-1 beta, IL-2, and IL-10; and 2) To analyze the neurological outcome after 72 h of ischemic stroke onset and expression of interleukins. Method: We measured the serum levels of IL-1 beta, IL-2, and IL-10 in 26 patients with acute stroke. Neurological impairment was scored using the National Institute of Health Stroke Scale within the first 72 h after stroke onset. Thirty healthy subjects were analyzed as controls. Results: Patients with IL-10 <925.0 pg/mL presented with neurological deterioration within the first 72 h. Conclusion: IL-10 may protect against ischemic injury during the acute phase of stroke.